You can change the default stream you see on the home page by dragging a friend list or network filter above “News Feed” on the left. Most people don’t know that this is possible, but it’s a powerful feature once you’ve created a friend list you like using a lot.
Now, you’ll only see updates from “Best Friends” (or whichever list you prefer seeing most often) when you load the home page.
You can only currently use friend lists and networks as your default News Feed filter - not applications. However, you can still rearrange applications in the section below friend lists and networks in order to put your favorite ones on top.